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B12 & 5-MTHF combines the most active, stable, and highly bioavailable forms of folic acid (Quatrefolic
® brand) and vitamin B12 (methylcobalamin)
B12 & 5-MTHF:
• The most stable, bioavailable and active form of folate and Vitamin B12
• Recommended for methylation, cellular health, and child-bearing years/ pregnancy*
• A preferred form of folate for the support of homocysteine management, heart health and nerve function*
• Gluten and soy free
• Made with non-gmo ingredients
is the active form of B12. It does not have to be converted so it starts working right away. It’s also the form used to make methionine synthase an enzyme that converts homocysteine into methionine. In fact 80% of B12 in the plasma is in the methylcobalamin form.
Folic Acid, Vitamin B12 and Pregnancy
Taking folic acid before and during pregnancy supports the development of a healthy brain and spinal cord. It is recommended that folic consumption begin within the first 3-4 weeks of pregnancy so it is important to have folic acid in your system during those early stages when the baby’s brain and spinal cord are developing. Quatrefolic® brand folate bypasses the need for enzymatic activation making it readily available to be used by the body. The active form of Vitamin B12 (methylcobalamin) has been included because the Recommended Dietary Allowance of Vitamin B12 is higher for pregnant women. Vitamin B12 is essential for the functioning of the nervous system and for the production of red blood cells.* Studies have shown that women with low levels of B12 put both themselves and baby at risk of health problems.*
Importance of Methylation
Methylation is the process of attaching methyl groups to a compound in order to produce other compounds or to protect an existing compound from damage. This process is important to good health and well-being as it contributes to a wide variety of bodily functions such as:
• Production of enzymes, hormones, neurotransmitters, antibodies, vitamins and cell membranes
• Energy production, immune function and detoxification
• Repairing and building DNA, brain activity and mood balancing
• Healthy inflammatory response, homocysteine management and neurological function
• Folic acid and Vitamin B12 are essential cofactors in the methylation process.
About Folic Acid
The terms "folate" and "folic acid" are often used interchangeably. It is a member of the B vitamin family and is necessary for methylation reactions in that it is required for the donation or transfer of methyl groups and for dontating its own methyl group to homocycteine in order to produce methionine for the production of SAMe, the principle methylating agent in the body. Folate is also required for healthy development of cells, brain function and protection from cell damage.
Folates are normally found in a wide variety of foods. However, they are unstable and susceptible to oxidation and rapidly lose activity during food processing, manufacturing and storage. Common folic acid supplements must be converted to its active form by an enzyme called methylenetetrahydrofolate reductase in order for it to be absorbed and utilized by the body. Several conditions such as an enzyme defect, malabsorption, digestive system challenges and poor liver function can lead to a folate deficiency. Lifestyle choices such as smoking, alcohol excess, eating disorders, low vegetables intake and chronic dieting such put people at risk of low folate levels. As a result, much of society is deficient due to poor metabolism of folic acid from either food or supplements.
B12 & 5-MTHF
uses the Quatrefolic® brand folate because it bypasses the need for enzymatic activation making it readily available to be used by the body. Supplement Facts
Serving Size 1 Capsule
Amount Per Serving
Folate (as [6S]-5-methyltetrahydrofolic acid from 2,000 mcg of Quatrefolic® [6S]-5-methyltetrahydrofolic acid,
glucosamine salt) 1,000 mcg Vitamin B12 (as Methylcobalamin) 1,000 mcg
Other ingredients: microcrystalline cellulose, vegetable cellulose (capsule), vegetarian leucine.
Warning: If pregnant or nursing, consult your healthcare practitioner before taking this product.
As a dietary supplement, take 1 capsule daily, or as directed by your healthcare practitioner.
Statements about products on this website have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease. If you are pregnant or nursing
consult a healthcare provider before use